The 2-Minute Rule for cees dekker
The 2-Minute Rule for cees dekker
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Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
[Laughs] ‘It absolutely was certainly a terrific danger! At time, I used to be perfectly aware that it could go Incorrect and that I could turn into significantly less successful, but I just ignored that. Curiosity has often been my strongest driving power. And by chance everything labored out.’
Considering that 2000, Dekker has shifted the primary focus of his get the job done in direction of biophysics where he scientific tests the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This modification of area was pushed by his fascination for your remarkable operating of biological molecular constructions, as well as via the prolonged-time period viewpoint that many exciting discoveries can be predicted in this discipline.[five] Existing strains of analysis in his biophysics team are within the regions of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and initial at any time review from the dynamics DNA supercoils and the discovery of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is that these parts together make up a residing method. The trick of stated lifetime, I believe, lies from the interactions, the interplay of All those molecules. The big problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from straightforward molecules into your very advanced methods we see currently? We do not know. I want to work on These types of big, open issues.’
Move-driven rotary motors like windmills and drinking water wheels push useful procedures in human Modern society. Although examples of this sort of rotary motors also attribute prominently in mobile biology, their artificial development within the nanoscale has remained challenging. Here we show circulation-driven rotary motion of a self-arranged DNA nanostructure which is docked onto a nanopore in a thin reliable-condition membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking onto the strong-state nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−one.
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It absolutely was all through this period that Dekker carried out investigation on magnetic spin devices and on sounds in superconductors and semiconductors.
In 1993 he was appointed as Associate Professor at Delft University of Technological know-how. Within the mid-nineties Dekker and his workforce accomplished accomplishment with the invention of the electronic Homes of carbon nanotubes, the main single-molecule ceesdekker.net transistor along with other nanoscience.
‘That fears the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down in Individuals times and discovered about five hundred genes that happen to be minimally needed for the performing cell. We want to glance bottom-up: how do we transfer from the handful of molecules to a whole Organic method?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and solitary-molecule experiments